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http://hdl.handle.net/20.500.11889/3934
Title: | The antioxidant activity of copper(II) (3,5-diisopropyl salicylate)4 and Its protective effect against streptozotocin-induced diabetes mellitus in rats | Authors: | Qazzaz, Munir Abdul-Ghani, Rula Metani, Munther Husein, Ratib Muhammad Abu Hijleh, Abdullatif Abdul Ghani, Abdul Salam |
Keywords: | Copper compounds - Physiological effect;Hypoglycemic agents;Antioxidants - Therapeutic use;Diabetes - Pathophysiology;Streptozotocin | Issue Date: | 2013 | Abstract: | Oxidative stress has been suggested as a potential contributor to the development of diabetic complications. In this study, we investigated the protective effect of a strong antioxidant copper complex against streptozotocin (STZ)-induced diabetes in animals. Out of four copper complexes used, copper(II) (3,5-diisopropyl salicylate)4 (Cu(II)DIPS) was found to be the most potent antioxidant-copper complex. Pretreatment with Cu(II)DIPS (5 mg/kg) twice a week prior to the injection of streptozotocin (50 mg/kg) has reduced the level of hyperglycemia by 34 % and the mortality rate by 29 %. Injection of the same dosage of the ligand 3,5-diisopropyl salicylate has no effect on streptozotocin-induced hyperglycemia. The same copper complex has neither hypoglycemic activity when injected in normal rats nor antidiabetic activity when injected in STZ-induced diabetic rats. The protective effect of Cu(II)DIPS could be related to its strong antioxidant activity compared to other copper complexes median effective concentration (MEC) = 23.84 μg/ml and to Trolox MEC = 29.30 μg/ml. In addition, it reduced serum 8-hydroxy-2'-deoxyguanosine, a biomarker of oxidative DNA damage, by 29 %. This effect may explain why it was not effective against diabetic rats, when β Langerhans cells were already destroyed. Similar protective activities were reported by other antioxidants like Trolox. | URI: | http://hdl.handle.net/20.500.11889/3934 |
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The Antioxidant Activity of Copper(II) (3,5-Diisopropyl Salicylate)4.pdf | 1.05 MB | Adobe PDF | View/Open |
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