Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/3934
DC Field | Value | Language |
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dc.contributor.author | Qazzaz, Munir | |
dc.contributor.author | Abdul-Ghani, Rula | |
dc.contributor.author | Metani, Munther | |
dc.contributor.author | Husein, Ratib Muhammad | |
dc.contributor.author | Abu Hijleh, Abdullatif | |
dc.contributor.author | Abdul Ghani, Abdul Salam | |
dc.date.accessioned | 2016-12-14T06:20:45Z | |
dc.date.available | 2016-12-14T06:20:45Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/3934 | |
dc.description.abstract | Oxidative stress has been suggested as a potential contributor to the development of diabetic complications. In this study, we investigated the protective effect of a strong antioxidant copper complex against streptozotocin (STZ)-induced diabetes in animals. Out of four copper complexes used, copper(II) (3,5-diisopropyl salicylate)4 (Cu(II)DIPS) was found to be the most potent antioxidant-copper complex. Pretreatment with Cu(II)DIPS (5 mg/kg) twice a week prior to the injection of streptozotocin (50 mg/kg) has reduced the level of hyperglycemia by 34 % and the mortality rate by 29 %. Injection of the same dosage of the ligand 3,5-diisopropyl salicylate has no effect on streptozotocin-induced hyperglycemia. The same copper complex has neither hypoglycemic activity when injected in normal rats nor antidiabetic activity when injected in STZ-induced diabetic rats. The protective effect of Cu(II)DIPS could be related to its strong antioxidant activity compared to other copper complexes median effective concentration (MEC) = 23.84 μg/ml and to Trolox MEC = 29.30 μg/ml. In addition, it reduced serum 8-hydroxy-2'-deoxyguanosine, a biomarker of oxidative DNA damage, by 29 %. This effect may explain why it was not effective against diabetic rats, when β Langerhans cells were already destroyed. Similar protective activities were reported by other antioxidants like Trolox. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Copper compounds - Physiological effect | en_US |
dc.subject | Hypoglycemic agents | en_US |
dc.subject | Antioxidants - Therapeutic use | en_US |
dc.subject | Diabetes - Pathophysiology | en_US |
dc.subject | Streptozotocin | en_US |
dc.title | The antioxidant activity of copper(II) (3,5-diisopropyl salicylate)4 and Its protective effect against streptozotocin-induced diabetes mellitus in rats | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | Human Biology, Medicine and Health Sciences | الطب والعلوم الطبية | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | other | - |
Appears in Collections: | Fulltext Publications |
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File | Description | Size | Format | |
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The Antioxidant Activity of Copper(II) (3,5-Diisopropyl Salicylate)4.pdf | 1.05 MB | Adobe PDF | View/Open |
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