Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/3934
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dc.contributor.authorQazzaz, Munir
dc.contributor.authorAbdul-Ghani, Rula
dc.contributor.authorMetani, Munther
dc.contributor.authorHusein, Ratib Muhammad
dc.contributor.authorAbu Hijleh, Abdullatif
dc.contributor.authorAbdul Ghani, Abdul Salam
dc.date.accessioned2016-12-14T06:20:45Z
dc.date.available2016-12-14T06:20:45Z
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/20.500.11889/3934
dc.description.abstractOxidative stress has been suggested as a potential contributor to the development of diabetic complications. In this study, we investigated the protective effect of a strong antioxidant copper complex against streptozotocin (STZ)-induced diabetes in animals. Out of four copper complexes used, copper(II) (3,5-diisopropyl salicylate)4 (Cu(II)DIPS) was found to be the most potent antioxidant-copper complex. Pretreatment with Cu(II)DIPS (5 mg/kg) twice a week prior to the injection of streptozotocin (50 mg/kg) has reduced the level of hyperglycemia by 34 % and the mortality rate by 29 %. Injection of the same dosage of the ligand 3,5-diisopropyl salicylate has no effect on streptozotocin-induced hyperglycemia. The same copper complex has neither hypoglycemic activity when injected in normal rats nor antidiabetic activity when injected in STZ-induced diabetic rats. The protective effect of Cu(II)DIPS could be related to its strong antioxidant activity compared to other copper complexes median effective concentration (MEC) = 23.84 μg/ml and to Trolox MEC = 29.30 μg/ml. In addition, it reduced serum 8-hydroxy-2'-deoxyguanosine, a biomarker of oxidative DNA damage, by 29 %. This effect may explain why it was not effective against diabetic rats, when β Langerhans cells were already destroyed. Similar protective activities were reported by other antioxidants like Trolox.en_US
dc.language.isoen_USen_US
dc.subjectCopper compounds - Physiological effecten_US
dc.subjectHypoglycemic agentsen_US
dc.subjectAntioxidants - Therapeutic useen_US
dc.subjectDiabetes - Pathophysiologyen_US
dc.subjectStreptozotocinen_US
dc.titleThe antioxidant activity of copper(II) (3,5-diisopropyl salicylate)4 and Its protective effect against streptozotocin-induced diabetes mellitus in ratsen_US
dc.typeArticleen_US
newfileds.departmentScienceen_US
newfileds.item-access-typeopen_accessen_US
newfileds.thesis-prognoneen_US
newfileds.general-subjectHuman Biology, Medicine and Health Sciences | الطب والعلوم الطبيةen_US
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