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Title: Catalytic activities of the antitumour complex bis(acetato)bis(imidazole)copper(II) and bis(valproato)bis(imidazole)copper(II) for the oxidation of organic substrates
Authors: Abu Hijleh, Abdullatif
Keywords: Tumors - Chemotherapy;Copper compounds - Therapeutic use
Issue Date: 1996
Abstract: Abstract The catalytic activities of the antitumour complex bis(acetate)bis(imidazole) copper(II) (1) and bis(valproato)bis(imidazole)copper(II) (2) toward the aerobic oxi-dation of N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD ) to T M P D + and 3,5-di-t-butylcatechol (DTBC) to 3,5-dit-butylobenzoquinone were determined. The rates were found to be first order with respect to both substrate and catalyst concentration. Com - plexes 1 and 2 were found to be effective catalysts for the oxidation cyclization of o-phenylenediamine (OPD) to 2,3-diaminophenazine, as well as oxidation of hydroquinone to 1,4-benzoquinone. The formation of a copper ion semiquinone species in solution, which may be the catalytic intermediate that reacts directly with oxygen, was demonstrated spectrophotometrically. The results suggested that the oxidation of OP D and D T B C takes place in two one-electron transfer steps. The copper(II) complex/OPD/PPh3 catalyst system was found to catalyse the oxidation of triphenylphosphine (PPh3) to P h 3 P ~ by molecular oxygen. The relevance o f these copper(II) complexes to the biological functions of copper-containing proteins are discussed.
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