Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/3971
DC Field | Value | Language |
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dc.contributor.author | Abu Hijleh, Abdullatif | - |
dc.date.accessioned | 2016-12-19T09:39:51Z | - |
dc.date.available | 2016-12-19T09:39:51Z | - |
dc.date.issued | 1996 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/3971 | - |
dc.description.abstract | Abstract The catalytic activities of the antitumour complex bis(acetate)bis(imidazole) copper(II) (1) and bis(valproato)bis(imidazole)copper(II) (2) toward the aerobic oxi-dation of N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD ) to T M P D + and 3,5-di-t-butylcatechol (DTBC) to 3,5-dit-butylobenzoquinone were determined. The rates were found to be first order with respect to both substrate and catalyst concentration. Com - plexes 1 and 2 were found to be effective catalysts for the oxidation cyclization of o-phenylenediamine (OPD) to 2,3-diaminophenazine, as well as oxidation of hydroquinone to 1,4-benzoquinone. The formation of a copper ion semiquinone species in solution, which may be the catalytic intermediate that reacts directly with oxygen, was demonstrated spectrophotometrically. The results suggested that the oxidation of OP D and D T B C takes place in two one-electron transfer steps. The copper(II) complex/OPD/PPh3 catalyst system was found to catalyse the oxidation of triphenylphosphine (PPh3) to P h 3 P ~ by molecular oxygen. The relevance o f these copper(II) complexes to the biological functions of copper-containing proteins are discussed. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Tumors - Chemotherapy | en_US |
dc.subject | Copper compounds - Therapeutic use | en_US |
dc.subject.lcsh | Tumor antigens | - |
dc.subject.lcsh | Catalysts - Therapeutic use | - |
dc.title | Catalytic activities of the antitumour complex bis(acetato)bis(imidazole)copper(II) and bis(valproato)bis(imidazole)copper(II) for the oxidation of organic substrates | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | Human Biology, Medicine and Health Sciences | الطب والعلوم الطبية | en_US |
item.grantfulltext | open | - |
item.languageiso639-1 | other | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Fulltext Publications |
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copper acetate-valproate.pdf | 772.46 kB | Adobe PDF | View/Open |
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