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http://hdl.handle.net/20.500.11889/8265
Title: | The antioxidant activity of copper(II) (3,5-diisopropyl salicylate) 4 and its protective effect against streptozotocin-induced diabetes mellitus in rats | Authors: | Qazzaz, Munir M. Abdul-Ghani, Rula Metani, Munther Husein, Rateb Abu-Hijleh, Abdul-Latif Abdul-Ghani, Abdul-Salam |
Keywords: | Copper complex;Antidiabetic;Antioxidants;Protective activity;Streptozotocin | Issue Date: | 2013 | Publisher: | Biological Trace Element Research | Abstract: | Oxidative stress has been suggested as a potential contributor to the development of diabetic complications. In this study, we investigated the protective effect of a strong antioxidant copper complex against streptozotocin (STZ)-induced diabetes in animals. Out of four copper complexes used, copper(II) (3,5-diisopropyl salicylate)4 (Cu(II)DIPS) was found to be the most potent antioxidant–copper complex. Pretreatment with Cu(II)DIPS (5 mg/kg) twice a week prior to the injection of streptozotocin (50 mg/kg) has reduced the level of hyperglycemia by 34 % and the mortality rate by 29 %. Injection of the same dosage of the ligand 3,5- diisopropyl salicylate has no effect on streptozotocin induced hyperglycemia. The same copper complex has neither hypoglycemic activity when injected in normal rats nor antidiabetic activity when injected in STZ-induced diabetic rats. The protective effect of Cu(II)DIPS could be related to its strong antioxidant activity compared to other copper complexes median effective concentration (MEC)=23.84 μg/ml and to Trolox MEC=29.30 μg/ml. In addition, it reduced serum 8-hydroxy-2′-deoxyguanosine, a biomarker of oxidative DNA damage, by 29 %. This effect may explain why it was not effective against diabetic rats, when β Langerhans cells were already destroyed. Similar protective activities were reported by other antioxidants like Trolox. | URI: | http://hdl.handle.net/20.500.11889/8265 | DOI: | 10.1007/s12011-013-9697-5 |
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