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Title: Effect of aqueous extract of Commiphora opobalsamum on blood pressure and heart rate in rats
Authors: Abdul-Ghani, Abdul-Salam 
Amin, R. 
Keywords: Functional foods - Analysis;Commiphora opobalsamum;Blood circulation;Blood pressure;Heart beat;Heart Rate;Receptors, Cholinergic;Atropine
Issue Date: 1997
Abstract: The cardiovascular effects of aqueous extracts from the branches of Commiphora opobalsamum tree were investigated. The intravenous administration of 4 mg/kg of the aqueous extract depressed systemic arterial blood pressure by 20% (PB0.01) and reduced heart rate of anaesthetised rats by 14% (PB0.05). The hypotensive and the bradycardic effects were immediate and in a dose related manner. The hypotensive effect of C. opobalsamum was inhibited by the pretreatment with atropine sulfate (1–4 mg/kg). These results suggest that the hypotensive effect of C. opobalsamum is due to the activation of muscarinic cholinergic receptors.
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