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Title: Functional Quorum Sensing Systems Affect Biofilm Formation and Protein Expression in Yersinia pestis
Authors: Abu Khweek, Arwa
Keywords: Gram-negative bacteria;Quorum sensing (Microbiology)
Issue Date: Feb-2007
Abstract: Gram-negative bacteria predominantly use two types of quorum sensing (QS) systems - LuxI-LuxR, responsible for synthesis of N-acylhomoserine lactones (AHL or AI-1 signal molecule), and LuxS, which makes furanones (AI-2 signal molecule). We showed that LuxS and two LuxI-LuxR (YtbIR and YpsIR) systems are functional in Y. pestis. Four different AHL molecules were detected in Y. pestis extracts using TLC bioassays. Our data suggest that YtbIR is responsible for the production of long chain AHLs. Confocal laser scanning microscopy showed that biofilm formation is decreased in an ytbIR ypsIR luxS mutant. Twodimensional gel electrophoresis revealed altered levels of protein expression in a Y. pestis triple QS mutant at 26o C and 37o C
Description: Authors include Alexander G. Bobrov, Scott W. Bearden, Jacqueline D. Fetherston,Kenneth D. Parrish, and Robert D. Perry
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