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Title: The N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNA.
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Authors: Stiban, Johnny
Farnum, Gregory
Hovde, Stacy
Kaguni, Laurie S.
Issue Date: 2014
Publisher: American Society of Biochemistry and Molecular Biology
Abstract: Background: Despite high evolutionary conservation, the function of the N-terminal domain (NTD) of mtDNA helicase remains elusive. Results: Drosophila NTD contains an iron-sulfur cluster and binds DNA. Conclusion: The iron-sulfur cluster in mtDNA helicase enhances protein stability, and may regulate its biological functions. Significance: Discovery of an Fe-S cluster in insect mtDNA helicase presents a novel opportunity to explore species-specific relationships in the replisome.
Description: Farnum,Gregory: Hovde,Stacy: S. Kaguni,Laurie:
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