Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/2610
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dc.contributor.authorStiban, Johnny
dc.contributor.authorFuterman, Tony
dc.date.accessioned2016-10-13T09:34:09Z
dc.date.available2016-10-13T09:34:09Z
dc.date.issued2010-1
dc.date.issued2010-1
dc.identifier.urihttp://hdl.handle.net/20.500.11889/2610
dc.descriptionFuterman,Tony:Department of Biological Chemistryen_US
dc.description.abstractCeramide synthases (CerS) are integral membrane proteins of the endoplasmic reticulum. Six mammalian CerS have been described, with each utilizing fatty acyl CoAs of relatively deined chain lengths for N‑acylation of the sphingoid long chain base. In this chapter, we review the main functional features of the CerS proteins, discuss their fatty acid speciicity, kinetics, tissue distribution and mode of inhibition, as well as possible posttranslational modiica‑ tions. We then address the reason that mammals contain six distinct CerS, whereas most other enzymes in the sphingolipid biosynthetic pathway only occur in one or two isoforms. Finally, we discuss the putative roles of CerS and the ceramide derived from the CerS, in signaling pathways and in development of disease
dc.language.isoenen_US
dc.publisherResearchGateen_US
dc.subject.lcshCellular signal transduction
dc.subject.lcshSphingolipids - Physiological effect
dc.subject.lcshSphingolipids
dc.subject.lcshCeramide Synthases
dc.titleCeramide Synthases: Roles in Cell Physiology and Signalingen_US
dc.typeArticleen_US
newfileds.departmentDepartment of Biology and Biochemistryen_US
newfileds.item-access-typeopen_accessen_US
item.grantfulltextopen-
item.languageiso639-1other-
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