Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/2610
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Stiban, Johnny | |
dc.contributor.author | Futerman, Tony | |
dc.date.accessioned | 2016-10-13T09:34:09Z | |
dc.date.available | 2016-10-13T09:34:09Z | |
dc.date.issued | 2010-1 | |
dc.date.issued | 2010-1 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/2610 | |
dc.description | Futerman,Tony:Department of Biological Chemistry | en_US |
dc.description.abstract | Ceramide synthases (CerS) are integral membrane proteins of the endoplasmic reticulum. Six mammalian CerS have been described, with each utilizing fatty acyl CoAs of relatively deined chain lengths for N‑acylation of the sphingoid long chain base. In this chapter, we review the main functional features of the CerS proteins, discuss their fatty acid speciicity, kinetics, tissue distribution and mode of inhibition, as well as possible posttranslational modiica‑ tions. We then address the reason that mammals contain six distinct CerS, whereas most other enzymes in the sphingolipid biosynthetic pathway only occur in one or two isoforms. Finally, we discuss the putative roles of CerS and the ceramide derived from the CerS, in signaling pathways and in development of disease | |
dc.language.iso | en | en_US |
dc.publisher | ResearchGate | en_US |
dc.subject.lcsh | Cellular signal transduction | |
dc.subject.lcsh | Sphingolipids - Physiological effect | |
dc.subject.lcsh | Sphingolipids | |
dc.subject.lcsh | Ceramide Synthases | |
dc.title | Ceramide Synthases: Roles in Cell Physiology and Signaling | en_US |
dc.type | Article | en_US |
newfileds.department | Department of Biology and Biochemistry | en_US |
newfileds.item-access-type | open_access | en_US |
item.grantfulltext | open | - |
item.languageiso639-1 | other | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Fulltext Publications |
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File | Description | Size | Format | |
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Stiban_Tidhar_and_Futerman-libre.pdf | 975.6 kB | Adobe PDF | View/Open |
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