Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/6732
Title: Pyroptotic and non-pyroptotic effector functions of caspase-11
Authors: Abu Khweek, Arwa 
Amer, Amal O. 
Keywords: Burkholderiales;Danger-associated molecular patterns;Caspase 1;Caspase 11;Inflammation - Diseases - Treatment;Gasdermin;Legionella;Legionnaires' disease;Pathogen-associated molecular patterns;Pyroptosis;Salmonella
Issue Date: 9-Jun-2020
Journal: Immunological reviews 
Abstract: infection or tissue injury, thus mounting regulated immune response. Inflammasomes are highly sophisticated and effective orchestrators of innate immunity. These oligomerized multiprotein complexes are at the center of various innate immune pathways, including modulation of the cytoskeleton, production and maturation of cytokines, and control of bacterial growth and cell death. Inflammasome assembly often results in caspase-1 activation, which is an inflammatory caspase that is involved in pyroptotic cell death and release of inflammatory cytokines in response to pathogen patterns and endogenous danger stimuli. However, the nature of stimuli and inflammasome components are diverse. Caspase-1 activation mediated release of mature IL-1β and IL-18 in response to canonical stimuli initiated by NOD-like receptor (NLR), and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC). On the other hand, caspase-11 delineates a non-canonical inflammasome that promotes pyroptotic cell death and non-pyroptotic functions in response to non-canonical stimuli. Caspase-11 in mice and its homologues in humans (caspase-4/5) belong to caspase-1 family of cysteine proteases, and play a role in inflammation. Knockout mice provided new genetic tools to study inflammatory caspases and revealed the role of caspase-11 in mediating septic shock in response to lethal doses of lipopolysaccharide (LPS). Recognition of LPS mediates caspase-11 activation, which promotes a myriad of downstream effects that include pyroptotic and non-pyroptotic effector functions. Therefore, the physiological functions of caspase-11 are much broader than its previously established roles in apoptosis and cytokine maturation. Inflammation induced by exogenous or endogenous agents can be detrimental and, if excessive, can result in organ and tissue damage. Consequently, the existence of sophisticated mechanisms that tightly regulate the specificity and sensitivity of inflammasome pathways provides a fine-tuning balance between adequate immune response and minimal tissue damage. In this review, we summarize effector functions of caspase-11.
URI: http://hdl.handle.net/20.500.11889/6732
Appears in Collections:Fulltext Publications

Files in This Item:
File Description SizeFormat
1-5.pdfPyroptotic and non-pyroptotic effector functions of caspase-11746.19 kBAdobe PDFView/Open
2-5.pdfCaspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation1.66 MBAdobe PDFView/Open
3-5.pdfCaspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages5 MBAdobe PDFView/Open
4-5.pdfBiofilm, a Cozy Structure for Legionella pneumophila Growth and Persistence in the Environment302.85 kBAdobe PDFView/Open
5-5.pdfBiofilm-Derived Legionella pneumophila Evades Activation of the NLRC4 Inflammasome1.29 MBAdobe PDFView/Open
6-5.pdfFactors Mediating Environmental Biofilm Formation by Legionella pneumophila959.91 kBAdobe PDFView/Open
5-7.pdfDefective immunometabolism pathways in cystic fibrosis macrophages ✩1.93 MBAdobe PDFView/Open
7-5.pdfDefective immunometabolism pathways in cystic fibrosis macrophages ✩1.93 MBAdobe PDFView/Open
8-5.pdfGasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo4.49 MBAdobe PDFView/Open
9-5.pdfInsights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma773.88 kBAdobe PDFView/Open
1-4.pdfAnalysis of HmsH and its role in plague biofilm formation746.83 kBAdobe PDFView/Open
3-4.pdfPeroxisome Proliferator-activated Receptors as Potential Targets for Carcinogenic Activity of Polychlorinated Biphenyls: A Computational Perspective313.87 kBAdobe PDFView/Open
4-4.PDFThe Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages2.78 MBAdobe PDFView/Open
5-4.pdfBiofilm-derivedLegionellapneumophilaevadestheinnateimmuneresponseinmacrophages2.05 MBAdobe PDFView/Open
6-4.pdfA bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy2.22 MBAdobe PDFView/Open
7-4.pdfDepletion of the ubiquitin binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery810.11 kBAdobe PDFView/Open
8-4.pdfCaspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization3.21 MBAdobe PDFView/Open
9-4.pdfActivation of the pyrin inflammasome by Intracellular Burkholderia cenocepacia944.7 kBAdobe PDFView/Open
10-4.pdfExaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients741.36 kBAdobe PDFView/Open
11-4.pdfAutophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis2.57 MBAdobe PDFView/Open
12-4.pdfASC CONTROLS LEGIONELLA PNEUMOPHILA INFECTION IN HUMAN MONOCYTES622.28 kBAdobe PDFView/Open
13-4.pdfAsc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages1.82 MBAdobe PDFView/Open
14-4.pdfBurkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1 production in macrophages1.06 MBAdobe PDFView/Open
15-4.pdfReplication of Legionella pneumophila in human cells: why are we susceptible?1.23 MBAdobe PDFView/Open
Show full item record

Page view(s)

123
checked on Feb 6, 2024

Download(s)

341
checked on Feb 6, 2024

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.