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|Title:||Sulfasalazine matrix coating with low mw DLPOLY (Lactic Acid)|
Vivo and in Vitro studies
|Abstract:||11th Panhellenic Pharmaceutical Congress 65 enhancer (M). The results were described by in vivo and in vitro studies. In vitro we used the Miblemman method and in vivo we used groups of 6 eats with weight near 120:1:10g. The contained in MET was counted on spectrophotometer UVN1S Jasco V530 at 15, 30, 60, 90 min. (A=257nm for MET) (2). The three formulas of suppositoria met the conditions of F.R.X concerning aspect, mass uniformity, melting characteristics and cantitative dosage..The kinetics of release and difuthion of sodium metamizole displayed.no significant differences between S and C formulas. The T formula had better results also in vitro and in viva In conclusion, the quantity of sodium metamizole which penetrated the biological membrane was higher when associating the penetration enhances for formulation T (90%), compared to standard sample M (79%).|
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