Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/4498
Title: Vesicle swelling regulates content expulsion during secretion
Authors: Kelly, Marie L.
Cho, Won Jin
Jeremic, Aleksandar
Abu Hamdah, Rania
Jena, Bhanu P.
Keywords: Secretion - Regulation;Synaptic vesicles
Issue Date: 2004
Publisher: Cell Biology International 28 (2004) 709-716
Abstract: The involvement of secretory vesicle swelling has been proposed in secretion; however, little is known about its role. Using both the pancreatic acinar cell and neuronal model, we show secretory vesicle swelling in live cells. Our study reveals that vesicle swelling potentiates its fusion at the cell plasma membrane, and is required for expulsion of intravesicular contents. Since the extent of swelling is directly proportional to the amount of vesicular contents expelled, this provides cells with the ability to regulate release of secretory products. These direct observations of the requirement of secretory vesicle swelling in secretion, provides an understanding of the appearance of partially empty vesicles following the process.
URI: http://hdl.handle.net/20.500.11889/4498
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