Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/4265
Title: Hypoglycemic effect of copper(ll) acetate imidazole complexes
Authors: Abdul Ghani, Abdul Salam
Abu Hijleh, Abdullatif
Nahas, Nabeel
Amin, Riyad
Keywords: Copper compounds - Physiological effect
Hypoglycemic agents
Acetates
Metal complexes
Organometallic compounds
Issue Date: 1996
Publisher: Humana Press Inc.
Abstract: The effect of copper(II) complexes on glucose metabolism was studied in normal and streptozotocin-induced diabetic rats. The copper(II) complexes used were bis(acetato)tetrakis(imidazole) copper(II), [Cu(OAc)2(Im)4], bis(acetato)bis(2-methylimidazole) copper(II), Cu(OAc)2(2mIm)2], bis(acetato)bis(1,2-dimethylimidazole) copper(II), Cu(OAc)2(1,2dmIm)2], and bis(acetato)bis(p-acetato)tetrakis(N-methylimidazole) copper(II) hexaaquo, [Cu2(OAc)4-(NmIm)4]-6H20. Intramuscular administration of various doses of Cu(OAc)2(Im)4 ranging from 10 to 100 mg/kg body mass to overnight fasted rats decreased blood glucose levels in a dose-dependent manner. Maximum hypoglycemic effect was observed 3 h after administration and lasted for at least 6 h. Treatment with 100 mg/kg body mass of Cu(OAc)2(Im)4 caused hypoglycemic shock, which was irreversible and even lethal. Blood insulin levels were reduced sharply during this hypoglycemic shock. Similar changes in blood glucose level were achieved using Cu(OAc)2(2mIm)2. The same pattern of hypoglycemia, although less pronounced, was observed for Cu2(OAc)4(NmIm)4-6H20 and Cu (OAc)2 (1,2dmlm)2. Binary copper(II) acetate complex, the ligand imidazole, and the inorganic form of copper, such as copper(II) chloride, had no significant effect on blood glucose level. These results indicate that the hypoglycemic activity of these complexes varies with the imidazole ligand and structure of the complex.
Description: copper acetate imidazoles complexes have Antidiabetic effect
URI: http://hdl.handle.net/20.500.11889/4265
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