Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/4218
DC Field | Value | Language |
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dc.contributor.author | Abu Hijleh, Abdullatif | - |
dc.date.accessioned | 2017-02-04T12:21:30Z | - |
dc.date.available | 2017-02-04T12:21:30Z | - |
dc.date.issued | 1997 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/4218 | - |
dc.description | SOD activities of copper complexes of the anticonvulsant drug valproate with diimines | en_US |
dc.description.abstract | Mononuclear complexes of the type [Cu(valp)z(2,2 --bpy)]H 2 0 (2), Cu(valp)2 (phen) (3), and Cu(valp)z(dmph) (4), and polynuclear complexes of the type [Cu(valp)z( µ-4,4 --bpy)]n (5), and [Cu 2 (valp)4 (µ-4,4 --bpy)Jn (6) [valp = valproate ion, bpy = bipyridine, phen = 1,10- phenanthroline, and dmph = 2,9-dimethyl-1,10- phenanthroline], were synthesized and characterized by magnetic and spectroscopic measurements. Spectral and magnetic data for complexes 2, 3, and 4 and the preliminary x-ray measurements for complex 3 are consistent with mononuclear structure. The copper atom in 2 and 3 is coordinated to two nitrogen atoms from diimine, two asymmetric carboxylic oxygen atoms from each of a bidentate valproate ions to give a tertragonally elongated CuN202 + 02 chromophore. The copper atom in com plex 4 is coordinated to two nitrogen atoms from dmph, two carboxylic oxygens of a bidentate valproate ion, and an oxygen atom of a monodentate carboxylic group of a second valproate ion to give a very distorted square pyramid or trigonal bipyramid CuN2O3 chromophore. The preceding data for 5 and 6 indicate that these complexes are polymeric in which the nitrogen atoms of 4,4 --bpy ligands bridge mononuclear Cu(valp)2 moities, coordinating equatorially in complex 5, while bridge binuclear Cu(µ-valp)4 Cu moities, coordinating axially in complex 6. The superoxide dismutase-mimetic activity of the binary complex, Cuz(valp)4 (1), and of the previous ternary complexes was measured and found to be in the order : 2 =3 > 6 > 4 > 1 > 5. | en_US |
dc.description.sponsorship | Birzeit University | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Copper compounds - Synthesis | en_US |
dc.subject | Copper compounds - Analysis | en_US |
dc.subject | Copper compounds - Spectra | en_US |
dc.subject.lcsh | Anticonvulsants - Analysis | - |
dc.subject.lcsh | Superoxide dismutase - Synthesis | - |
dc.title | Ternary copper(II) Complexes of the anticonvulsant drug valproate with diimines as superoxide dismutase mimics | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | Natural Sciences | العلوم الطبيعية | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | other | - |
Appears in Collections: | Fulltext Publications |
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1-s2.0-S0162013497000433-main[1].pdf | 848.46 kB | Adobe PDF | View/Open |
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