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Title: Synthesis, Characterization and Biological Activity of Novel Transition Metal Complexes Based on the Biologically Active
Authors: Abu Ali, Hijazi
Maloul, Salam
Darawsheh, Mohanad D.
Omar, Suhad Nizar
Fares, Hadeel Hassan
Jabali, Baha' H.
Shalash, Asia
Kamel, S.
Abu Shamma, A.
Rappocciolo, Emilia
Akkawi, Mutaz
Jaber, Suhair
Keywords: Chemistry, Pharmaceutical
Metals - Therapeutic use
Issue Date: 2016
Abstract: Some novel transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] complexes of substituted pyridine Schiff-bases have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff-bases act as deprotonated tridentate for the complexation reaction with Co(II), Ni(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)2] where [M=Co(II), Cu(II), Ni(II) and Zn(II) and HL=HL1, HL2, HL3 and HL4] show an octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff bases and their complexes have been screened for antibacterial activity against the strains such as Escherichia coli,Staphylococcus aureus, and Pseudomonas aeruginosa. The complexed Schiff bases have shown to be more antibacterial against one more bacterial species as compared to uncomplexed Schiff-bases.
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