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dc.contributor.authorRayyan, Saleh
dc.contributor.authorFossen, Torgils
dc.contributor.authorNateland, Harvard Solheim
dc.contributor.authorAndersen, Oyvind M.
dc.description.abstractTwelve flavonoids, including seven flavones, four flavonols and one flavanone, were isolated from methanolic extract of the herbal drug ‘Crataegi folium cum flore’ (hawthorn leaves and flowers) by a combination of CC (over Amberlite XAD-7 and Sephadex LH-20) and preparative HPLC. Their structures, including that of the novel flavonol 8-methoxykaempferol 3-O-(6″-malonyl-β-glucopyranoside), were elucidated by homoand heteronuclear NMR and electrospray/MS. The 1H- and 13C-NMR of all compounds, including rotameric pairs of five flavone C-glycosides, were assigned. The presence and relative proportion of each rotamer was shown by various NMR experiments, including two-dimensional nuclear Overhauser and exchange spectroscopy, to depend on solvent, linkage position and structure of the C-glycosyl substituent.en_US
dc.subjectMateria medica, Vegetable - Analysisen_US
dc.subjectFlavonoids - Spectraen_US
dc.subjectFlavonoids - Therapeutic useen_US
dc.titleIsolation and identification of flavonoids, including flavone rotamers, from the herbal drug ‘Crataegi Folium Cum Flore’ (Hawthorn)en_US
newfileds.general-subjectNatural Sciences | العلوم الطبيعيةen_US
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