Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/3996
Title: | Isolation and identification of flavonoids, including flavone rotamers, from the herbal drug ‘Crataegi Folium Cum Flore’ (Hawthorn) | Authors: | Rayyan, Saleh Fossen, Torgils Nateland, Harvard Solheim Andersen, Oyvind M. |
Keywords: | Materia medica, Vegetable - Analysis;Flavonoids - Spectra;Flavonoids - Therapeutic use | Issue Date: | 2005 | Abstract: | Twelve flavonoids, including seven flavones, four flavonols and one flavanone, were isolated from methanolic extract of the herbal drug ‘Crataegi folium cum flore’ (hawthorn leaves and flowers) by a combination of CC (over Amberlite XAD-7 and Sephadex LH-20) and preparative HPLC. Their structures, including that of the novel flavonol 8-methoxykaempferol 3-O-(6″-malonyl-β-glucopyranoside), were elucidated by homoand heteronuclear NMR and electrospray/MS. The 1H- and 13C-NMR of all compounds, including rotameric pairs of five flavone C-glycosides, were assigned. The presence and relative proportion of each rotamer was shown by various NMR experiments, including two-dimensional nuclear Overhauser and exchange spectroscopy, to depend on solvent, linkage position and structure of the C-glycosyl substituent. | URI: | http://hdl.handle.net/20.500.11889/3996 |
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Isolation and identification of flavonoids including flavone 2005.pdf | 191.69 kB | Adobe PDF | View/Open |
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