Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/3934
Title: The antioxidant activity of copper(II) (3,5-diisopropyl salicylate)4 and Its protective effect against streptozotocin-induced diabetes mellitus in rats
Authors: Qazzaz, Munir
Abdul-Ghani, Rula
Metani, Munther
Husein, Ratib Muhammad
Abu Hijleh, Abdullatif
Abdul Ghani, Abdul Salam
Keywords: Copper compounds - Physiological effect
Hypoglycemic agents
Antioxidants - Therapeutic use
Diabetes - Pathophysiology
Streptozotocin
Issue Date: 2013
Abstract: Oxidative stress has been suggested as a potential contributor to the development of diabetic complications. In this study, we investigated the protective effect of a strong antioxidant copper complex against streptozotocin (STZ)-induced diabetes in animals. Out of four copper complexes used, copper(II) (3,5-diisopropyl salicylate)4 (Cu(II)DIPS) was found to be the most potent antioxidant-copper complex. Pretreatment with Cu(II)DIPS (5 mg/kg) twice a week prior to the injection of streptozotocin (50 mg/kg) has reduced the level of hyperglycemia by 34 % and the mortality rate by 29 %. Injection of the same dosage of the ligand 3,5-diisopropyl salicylate has no effect on streptozotocin-induced hyperglycemia. The same copper complex has neither hypoglycemic activity when injected in normal rats nor antidiabetic activity when injected in STZ-induced diabetic rats. The protective effect of Cu(II)DIPS could be related to its strong antioxidant activity compared to other copper complexes median effective concentration (MEC) = 23.84 μg/ml and to Trolox MEC = 29.30 μg/ml. In addition, it reduced serum 8-hydroxy-2'-deoxyguanosine, a biomarker of oxidative DNA damage, by 29 %. This effect may explain why it was not effective against diabetic rats, when β Langerhans cells were already destroyed. Similar protective activities were reported by other antioxidants like Trolox.
URI: http://hdl.handle.net/20.500.11889/3934
Appears in Collections:Fulltext Publications

Files in This Item:
File Description SizeFormat 
The Antioxidant Activity of Copper(II) (3,5-Diisopropyl Salicylate)4.pdf1.05 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.