Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/3931
DC Field | Value | Language |
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dc.contributor.author | Darawsheh, Mohanad D. | - |
dc.contributor.author | Abu Ali, Hijazi | - |
dc.contributor.author | Abu Hijleh, Abdullatif | - |
dc.contributor.author | Rappocciolo, Emilia | - |
dc.contributor.author | Akkawi, Mutaz | - |
dc.contributor.author | Jaber, Suhair | - |
dc.contributor.author | Maloul, Salam | - |
dc.contributor.author | Hussein, Yasmeen | - |
dc.date.accessioned | 2016-12-13T12:33:33Z | - |
dc.date.available | 2016-12-13T12:33:33Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/3931 | - |
dc.description.abstract | Starting from the precursor [Zinc Valproate complex] (1), new mixed ligand zinc(II) complexes of valproic acid and nitrogen-based ligands, formulating as, [Zn(valp)22,9-dmphen] (2), [Zn2(valp)4(quin)2] (3), [Zn(valp)2(2-ampy)2] (4), and [Zn(valp)2(2-ampic)2] (5) (valp = valproate, 2,9-dmphen = 2,9-dimethyl-1,10-phenanthroline, quin = quinoline, 2-ampy = 2-aminopyridine, 2-ampic = 2-amino-6-picoline) were synthesized and characterized using IR, (1)H NMR, (13)C{(1)H} NMR and UV-Vis spectrometry. The crystal structures of complexes 2, 3 and 4 were determined using single-crystal X-ray diffraction. The complexes were also evaluated for their anti-bacterial activity using in-vitro agar diffusion method against three Gram-positive (Micrococcus luteus, Staphylococcus aureus, and Bacillus subtilis) and three Gram-negative (Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis) species. Complex 2 showed considerable activity against all tested microorganisms and the effect of complexation on the anti-bacterial activity of the parent ligand of 2 was also investigated. The anti-bacterial activity of 2,9-dmphen against Gram-negative bacteria was enhanced upon complexation with zinc valproate. On the other hand, complexes 1 and 3 showed weak inhibition activity against the tested species and complexes 4 and 5 didn't show any activity at all. Two methods were used for testing the inhibition of ferriprotoporphyrinIX bio-mineralization: a semi-quantitative micro-assay and a previously self-developed quantitative in-vitro method. Both were used to study the efficiency of these complexes in inhibiting the formation of the Malaria pigment which considered being the target of many known anti-malarial drugs such as Chloroquine and Amodiaquine. Results showed that the efficiency of complex 2 in preventing the formation of β-Hematin was 80%. The efficiency of Amodiaquine as a standard drug was reported to give 91%. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Zinc compounds - Synthesis | en_US |
dc.subject | Zinc compounds - Therapeutic use | en_US |
dc.subject | Antibacterial agents | en_US |
dc.subject | Antimalarials | en_US |
dc.subject | Ligands (Biochemistry) | en_US |
dc.subject | X-ray crystallography | en_US |
dc.subject | Nuclear magnetic resonance spectroscopy | en_US |
dc.title | New mixed ligand zinc(II) complexes based on the antiepileptic drug sodium valproate and bioactive nitrogen-donor ligands. Synthesis, structure and biological properties | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | Human Biology, Medicine and Health Sciences | الطب والعلوم الطبية | en_US |
item.languageiso639-1 | other | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
Appears in Collections: | Fulltext Publications |
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