Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/3931
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dc.contributor.authorDarawsheh, Mohanad D.-
dc.contributor.authorAbu Ali, Hijazi-
dc.contributor.authorAbu Hijleh, Abdullatif-
dc.contributor.authorRappocciolo, Emilia-
dc.contributor.authorAkkawi, Mutaz-
dc.contributor.authorJaber, Suhair-
dc.contributor.authorMaloul, Salam-
dc.contributor.authorHussein, Yasmeen-
dc.date.accessioned2016-12-13T12:33:33Z-
dc.date.available2016-12-13T12:33:33Z-
dc.date.issued2014-
dc.identifier.urihttp://hdl.handle.net/20.500.11889/3931-
dc.description.abstractStarting from the precursor [Zinc Valproate complex] (1), new mixed ligand zinc(II) complexes of valproic acid and nitrogen-based ligands, formulating as, [Zn(valp)22,9-dmphen] (2), [Zn2(valp)4(quin)2] (3), [Zn(valp)2(2-ampy)2] (4), and [Zn(valp)2(2-ampic)2] (5) (valp = valproate, 2,9-dmphen = 2,9-dimethyl-1,10-phenanthroline, quin = quinoline, 2-ampy = 2-aminopyridine, 2-ampic = 2-amino-6-picoline) were synthesized and characterized using IR, (1)H NMR, (13)C{(1)H} NMR and UV-Vis spectrometry. The crystal structures of complexes 2, 3 and 4 were determined using single-crystal X-ray diffraction. The complexes were also evaluated for their anti-bacterial activity using in-vitro agar diffusion method against three Gram-positive (Micrococcus luteus, Staphylococcus aureus, and Bacillus subtilis) and three Gram-negative (Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis) species. Complex 2 showed considerable activity against all tested microorganisms and the effect of complexation on the anti-bacterial activity of the parent ligand of 2 was also investigated. The anti-bacterial activity of 2,9-dmphen against Gram-negative bacteria was enhanced upon complexation with zinc valproate. On the other hand, complexes 1 and 3 showed weak inhibition activity against the tested species and complexes 4 and 5 didn't show any activity at all. Two methods were used for testing the inhibition of ferriprotoporphyrinIX bio-mineralization: a semi-quantitative micro-assay and a previously self-developed quantitative in-vitro method. Both were used to study the efficiency of these complexes in inhibiting the formation of the Malaria pigment which considered being the target of many known anti-malarial drugs such as Chloroquine and Amodiaquine. Results showed that the efficiency of complex 2 in preventing the formation of β-Hematin was 80%. The efficiency of Amodiaquine as a standard drug was reported to give 91%.en_US
dc.language.isoen_USen_US
dc.subjectZinc compounds - Synthesisen_US
dc.subjectZinc compounds - Therapeutic useen_US
dc.subjectAntibacterial agentsen_US
dc.subjectAntimalarialsen_US
dc.subjectLigands (Biochemistry)en_US
dc.subjectX-ray crystallographyen_US
dc.subjectNuclear magnetic resonance spectroscopyen_US
dc.titleNew mixed ligand zinc(II) complexes based on the antiepileptic drug sodium valproate and bioactive nitrogen-donor ligands. Synthesis, structure and biological propertiesen_US
dc.typeArticleen_US
newfileds.departmentScienceen_US
newfileds.item-access-typeopen_accessen_US
newfileds.thesis-prognoneen_US
newfileds.general-subjectHuman Biology, Medicine and Health Sciences | الطب والعلوم الطبيةen_US
item.languageiso639-1other-
item.fulltextWith Fulltext-
item.grantfulltextopen-
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