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|Title:||The N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNA.|
Kaguni, Laurie S.
|Publisher:||American Society of Biochemistry and Molecular Biology|
|Abstract:||Background: Despite high evolutionary conservation, the function of the N-terminal domain (NTD) of mtDNA helicase remains elusive. Results: Drosophila NTD contains an iron-sulfur cluster and binds DNA. Conclusion: The iron-sulfur cluster in mtDNA helicase enhances protein stability, and may regulate its biological functions. Significance: Discovery of an Fe-S cluster in insect mtDNA helicase presents a novel opportunity to explore species-specific relationships in the replisome.|
|Description:||Farnum,Gregory: Hovde,Stacy: S. Kaguni,Laurie:|
|Appears in Collections:||Fulltext Publications|
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