Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/2685
Title: Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: The Hordaland Homocysteine Study
Authors: El-Khairy, Lina
Ueland, Per M.
Nygard, Ottar
Refsum, Helga
Vollset, Stein
Issue Date: 1999
Publisher: American society for clinical nutrition
Abstract: Background: Plasma total homocysteine (tHcy) is a cardiovascular disease risk factor and is related to several components of the established cardiovascular disease risk profile. Cysteine is structurally and metabolically related to homocysteine, but data on its association with cardiovascular disease and cardiovascular disease risk factors are sparse. Objective: Our objective was to search for the determinants of plasma total cysteine (tCys) and compare them with those of tHcy. Design: In this cross-sectional study, we studied 7591 healthy men and 8585 healthy women aged 40–67 y with no history of hypertension, diabetes mellitus, coronary heart disease, or cerebrovascular disease. Results: In the group aged 40–42 y, tCys was significantly higher in men (x –: 273 mmol/L; 2.5–97.5 percentile: 219–338 mmol/L) than in women (253 mmol/L; 202–317 mmol/L) (P < 0.001). In the group aged 65–67 y, there was no significant sex difference in tCys: men (296 mmol/L; 233–362 mmol/L) and women (296 mmol/L; 234–361 mmol/L). As with tHcy, tCys was positively associated with age, total cholesterol concentration, diastolic blood pressure, and coffee consumption. Body mass index was a strong determinant of tCys but was not related to tHcy. Several factors known to influence tHcy, including smoking status, folate and vitamin intake, heart rate, and physical activity, were not associated or were only weakly associated with tCys. Conclusion: Plasma tCys is strongly related to several factors that constitute the cardiovascular disease risk profile. This should be an incentive to determine the role of tCys in cardiovascular disease.
URI: http://hdl.handle.net/20.500.11889/2685
Appears in Collections:Fulltext Publications

Files in This Item:
File Description SizeFormat 
10927.pdf164.44 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.