Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/2661
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dc.contributor.authorKafri, Mohannad W.
dc.contributor.authorDoherty, Danielle
dc.contributor.authorWilson, Alexander
dc.contributor.authorPotter, John
dc.contributor.authorHooper, Lee
dc.contributor.authorMyint, Phyo K.
dc.date.accessioned2016-10-15T08:53:27Z
dc.date.available2016-10-15T08:53:27Z
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/20.500.11889/2661
dc.description.abstractBackground: Non-invasive methods for detecting water-loss dehydration following acute stroke would be clinically useful. We evaluated the diagnostic accuracy of multi-frequency bioelectrical impedance analysis (MF-BIA) against reference standards serum osmolality and osmolarity. Material/Methods: Patients admitted to an acute stroke unit were recruited. Blood samples for electrolytes and osmolality were taken within 20 minutes of MF-BIA. Total body water (TBW%), intracellular (ICW%) and extracellular water (ECW%), as percentages of total body weight, were calculated by MF-BIA equipment and from impedance measures using published equations for older people. These were compared to hydration status (based on serum osmolality and calculated osmolarity). The most promising Receiver Operating Characteristics curves were plotted. Results: 27 stroke patients were recruited (mean age 71.3, SD10.7). Only a TBW% cut-off at 46% was consistent with current dehydration (serum osmolality >300 mOsm/kg) and TBW% at 47% impending dehydration (calculated osmolarity ≥295–300 mOsm/L) with sensitivity and specificity both >60%. Even here diagnostic accuracy of MF-BIA was poor, a third of those with dehydration were wrongly classified as hydrated and a third classified as dehydrated were well hydrated. Secondary analyses assessing diagnostic accuracy of TBW% for men and women separately, and using TBW as a percentage of lean body mass showed some promise, but did not provide diagnostically accurate measures across the population. Conclusions: MF-BIA appears ineffective at diagnosing water-loss dehydration after stroke and cannot be recommended as a test for dehydration, but separating assessment by sex, and using TBW as a percentage of lean body weight may warrant further investigation
dc.language.isoenen_US
dc.publisherMedical Science Monitoren_US
dc.subject.lcshBody fluids
dc.subject.lcshDehidration
dc.subject.lcshImpedance, Bioelectric
dc.subject.lcshBody fluid disorders
dc.subject.lcshOsmoregulation
dc.subject.lcshDiagnosis, Laboratory - Standards
dc.subject.lcshOsmosis
dc.subject.lcshBiological transport
dc.titleThe diagnostic accuracy of multi-frequency bioelectrical impedance analysis in diagnosing dehydration after strokeen_US
newfileds.item-access-typeopen_accessen_US
newfileds.general-subjectAlternative and Other Medicineen_US
item.languageiso639-1other-
item.fulltextWith Fulltext-
item.grantfulltextopen-
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