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|Title:||Studies on the reaction of ferric iron with glutathione and some related thiols. Part III. A study of the iron catalyzed oxidation of glutathione by molecular oxygen|
|Abstract:||Since the discovery of glutathione (GSH) by Hopkins and the recognition that this thiol could play a role in electron transfer [l-3], there have been many studies of the autocatalytic oxidation of this biologically important compound [l-4] and other related thiols [S-11]. The very low auto-oxidation of cysteine is accelerated by small quantities of iron . And it is interesting to note that iron is always associated with cysteine and glutathione [1, 2, 5, 6, 12, 131 in biological systems. Warburg and Sauma  demonstrated that cysteine in aqueous solutions was not oxidized by atmospheric oxygen in the absence of heavy metals and Harrison  showed that this was true also for glutathione. The effects of traces of heavy metals like Cu2+ and Fe3+ on the oxidation of cysteine, glutathione, and other thiols have been reported in other studies [ 1,3] . Once the need for the metal catalyst was confirmed [l] , attempts were made to derive a mecha- *Authors to whom correspondence should be addressed. 0020-1693/83/$3.00 nism for this catalytic process [7-l 1, 14, 151. These were based on reduction potentials, reduction capacity and kinetic data|
|Description:||Jack,Silver:Brunel University London Michael,Wilson:University of Essex|
|Appears in Collections:||Fulltext Publications|
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