Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/7837
Title: Changes in γ-aminobutyric acid during different stages of picrotoxin-induced seizure, and the effect of pretreatment with γ-acetylenic GABA and phenobarbital
Authors: Abdul-Ghani, Abdul-Salam 
Keywords: GABA;y-aminobutyric Acid;Picrotoxin;Convulsions - Treatment;Phenobarbital
Issue Date: 1989
Publisher: Journal of Biosciences
Abstract: Changes in GABA content of various brain areas during different stages of picrotoxin-induced seizures and following pretreatment with the anti-convulsants phenobarbital and γ-acetylenic GABA were studied. Picrotoxin (6mg/kg) produced clonic/tonic convulsions associated with a 34% reduction in GABA content of the sensory motor cortex. A reduction of 24% was observed 1 min before the onset of seizure and the reduction in GABA content was reversible 20 min after the convulsion. No significant changes were observed in the cerebellum or spinal cord/medulla oblongata. Pretreatment with phenobarbital (100mg/kg) delayed the onset of convulsion and decreased the mortality rate without causing any change in GABA content at the preconvulsive, convulsive or post-convulsive stages. γ-Acetylenic GABA (100mg/kg) has elevated GABA levels in different areas of the brain by 2-3-fold after 60 min treatment. This increase was reduced by 44% during the onset of picrotoxin-induced seizures. Picrotoxin convulsion can occur in the presence of normal, reduced or even elevated brain GABA content. The only consistent factor is a one-third reduction in GABA content before the onset of seizure
URI: http://hdl.handle.net/20.500.11889/7837
DOI: 10.1007/BF02703523
Appears in Collections:Fulltext Publications

Show full item record

Page view(s)

80
checked on Jun 27, 2024

Download(s)

15
checked on Jun 27, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.