Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11889/6708
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dc.contributor.authorAhmad, Ajazen_US
dc.contributor.authorAlqahtani, Saeeden_US
dc.contributor.authorJan, Basit Latiefen_US
dc.contributor.authorRaish, Mohammaden_US
dc.contributor.authorRabba, Abdullah K.en_US
dc.contributor.authorAlkharfy, Khalid M.en_US
dc.date.accessioned2021-03-10T12:46:56Z-
dc.date.available2021-03-10T12:46:56Z-
dc.date.issued2020-04-
dc.identifier.issn1319-0164-
dc.identifier.urihttp://hdl.handle.net/20.500.11889/6708-
dc.descriptionAn article published in : Saudi Pharmaceutical Journal, issue 28 (2020) pp. 403–408en_US
dc.description.abstractThymoquinone is the most biologically active constituent of Nigella sativa (black seed). A monoterpene compound chemically known as 2-methyl-5-isopropyl-1, 4-quinone. In this study, the gender-dependent pharmacokinetic behavior of thymoquinone in rats was investigated. Thymoquinone was administered orally (20 mg/kg) and intravenously (5 mg/kg) to male and female rats and blood samples were collected at specific time points. Plasma concentration-time curves were plotted and pharmacokinetic parameters were determined using the non-compartmental analysis. In addition, simulations of steady state concentrations of thymoquinone in male and female rats were performed using GastroPlus PK software. After oral administration, the maximum plasma concentration (Cmax) of thymoquinone was 4.52 ± 0.092 μg/ml in male rats and 5.22 ± 0.154 μg/ml in female rats (p = 0.002). Similarly, after intravenous administration, the Cmax was 8.36 ± 0.132 μg/ml in males and 9.51 ± 0.158 μg/ml in females (p = 0.550). The area under the plasma concentration-time curve (AUC)0-∞ following oral dosing was 47.38 ± 0.821 μg/ml·h in females and 43.63 ± 0.953 μg/ml·h in males (p = 0.014). Pharmacokinetics and plasma concentration vs. time profiles for multiple oral doses of thymoquinone in rats were predicted using a simulation model to compare the simulation results with the experimental plasma pharmacokinetic data. The differences observed in thymoquinone pharmacokinetics between male and female rats after a single dose were not evident for the simulated steady-state parameters. The findings suggest that the gender difference does not seem to play a significant role in thymoquinone disposition at steady state.en_US
dc.language.isoenen_US
dc.publisherSaudi Pharmaceutical Journalen_US
dc.relation.ispartofSaudi Pharmaceutical Journalen_US
dc.subjectThymoquinone - Physiological effecten_US
dc.subjectPharmacokineticsen_US
dc.subjectBlood lipidsen_US
dc.subjectBlack cumin - Therapeutic useen_US
dc.titleGender effect on the pharmacokinetics of thymoquinone : preclinical investigation and in silico modeling in male and female ratsen_US
dc.typeArticleen_US
newfileds.departmentPharmacy - Nursing and Health Professionsen_US
newfileds.item-access-typeopen_accessen_US
newfileds.thesis-prognoneen_US
newfileds.general-subjectnoneen_US
dc.identifier.doi10.1016/j.jsps.2020.01.022-
dc.identifier.pmid32273798-
item.fulltextWith Fulltext-
item.languageiso639-1other-
item.grantfulltextopen-
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