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Title: Iron-sulfur clusters in nucleic acid metabolism : varying roles of ancient cofactors
Authors: Khodour, Yara 
Kaguni, Lauri S. 
Stiban, Johnny 
Keywords: Transferases;Iron–sulfur clusters;Nucleic acids - Metabolism;DNA;DNA repair;DNA replication;Gene editing;Gene expression;Genomes;Genomics;Microclusters
Issue Date: 2019
Publisher: Elsevier
Source: The Enzymes, Volume 45, p. 225-256 # 2019
Abstract: Despite their relative simplicity, iron-sulfur clusters have been omnipresent as cofactors in myriad cellular processes such as oxidative phosphorylation and other respiratory pathways. Recent research advances confirm the presence of different clusters in enzymes involved in nucleic acid metabolism. Iron-sulfur clusters can therefore be considered hallmarks of cellular metabolism. Helicases, nucleases, glycosylases, DNA polymerases and transcription factors, among others, incorporate various types of clusters that serve differing roles. In this chapter, we review our current understanding of the identity and functions of iron-sulfur clusters in DNA and RNA metabolizing enzymes, highlighting their importance as regulators of cellular function.
Description: An article published in journal : The Enzymes, Volume 45, pp. 225-256 # 2019 Elsevier Inc. ISSN 1874-6047
ISBN: 9780128173961
ISSN: 0423-2607
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