Copper(II) complexes of anti-inflammatory drugs with nitrogen based ligands : synthesis, characterization and biological activities

Abstract

Copper(II) complexes of Anti-inflammatory drugs with Nitrogen Based Ligands: Synthesis, Characterization and Biological Activities. Copper(II) complexes of two non-steroidal anti-inflammatory drugs (NSAIDs) (naproxen (nap) and salicylate (sal)) with nitrogen donor ligands pyrazole (pz) and metronidazole (mtnd), [Cu(sal)2(pz)2] (1), [Cu(nap)2(pz)4] (2), [Cu2(nap)4(mtnd)2] (3) have been synthesized and spectroscopically characterized. The crystal structure of complex (1) has been determined by X-ray crystallography. The Cu(II) ion coordination consist of nitrogen atom (Ni) of pyrazoles and oxygen atom (01) of the salicylate carboxylate groups to yield trans-CuN2O2+02 chromophore. The catalytic activities of complexes toward the aerobic oxidations of 3,5-di-tert-butylcatechol (3,5-DTBC) to 3,5-di-tert-butyl-o-benzoquinone (3,5-DTBQ), 0-phenylenediamine (OPD) to 2,3- diaminophenazine (DAP) and 2-aminophenol (OAP) to 2-amino-3H-phenoxazine-3-one (APX) have been studied. The catalytic activities of these complexes mimic those of copper-containing enzymes catecholase and phenoxazinone synthase.[1,2]