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dc.contributor.authorAbdul Ghani, Abdul Salam
dc.contributor.authorAbu Hijleh, Abdullatif
dc.contributor.authorNahas, Nabeel
dc.contributor.authorAmin, Riyad
dc.descriptioncopper acetate imidazoles complexes have Antidiabetic effecten_US
dc.description.abstractThe effect of copper(II) complexes on glucose metabolism was studied in normal and streptozotocin-induced diabetic rats. The copper(II) complexes used were bis(acetato)tetrakis(imidazole) copper(II), [Cu(OAc)2(Im)4], bis(acetato)bis(2-methylimidazole) copper(II), Cu(OAc)2(2mIm)2], bis(acetato)bis(1,2-dimethylimidazole) copper(II), Cu(OAc)2(1,2dmIm)2], and bis(acetato)bis(p-acetato)tetrakis(N-methylimidazole) copper(II) hexaaquo, [Cu2(OAc)4-(NmIm)4]-6H20. Intramuscular administration of various doses of Cu(OAc)2(Im)4 ranging from 10 to 100 mg/kg body mass to overnight fasted rats decreased blood glucose levels in a dose-dependent manner. Maximum hypoglycemic effect was observed 3 h after administration and lasted for at least 6 h. Treatment with 100 mg/kg body mass of Cu(OAc)2(Im)4 caused hypoglycemic shock, which was irreversible and even lethal. Blood insulin levels were reduced sharply during this hypoglycemic shock. Similar changes in blood glucose level were achieved using Cu(OAc)2(2mIm)2. The same pattern of hypoglycemia, although less pronounced, was observed for Cu2(OAc)4(NmIm)4-6H20 and Cu (OAc)2 (1,2dmlm)2. Binary copper(II) acetate complex, the ligand imidazole, and the inorganic form of copper, such as copper(II) chloride, had no significant effect on blood glucose level. These results indicate that the hypoglycemic activity of these complexes varies with the imidazole ligand and structure of the complex.en_US
dc.description.sponsorshipBirzeit Universityen_US
dc.publisherHumana Press Inc.en_US
dc.subjectCopper compounds - Physiological effecten_US
dc.subjectHypoglycemic agentsen_US
dc.subjectMetal complexesen_US
dc.subjectOrganometallic compoundsen_US
dc.titleHypoglycemic effect of copper(ll) acetate imidazole complexesen_US
newfileds.corporate-authorAbdul-Salam Abdul-Ghani, Nabeel Nahas, and Riyad Aminen_US
newfileds.general-subjectHuman Biology, Medicine and Health Sciences | الطب والعلوم الطبيةen_US
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