Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/4212
DC Field | Value | Language |
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dc.contributor.author | Abu Hijleh, Abdullatif | - |
dc.date.accessioned | 2017-02-04T10:51:10Z | - |
dc.date.available | 2017-02-04T10:51:10Z | - |
dc.date.issued | 1997 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/4212 | - |
dc.description | Copper ibuprofen complexes were used to hydrolyzed phosphates | en_US |
dc.description.abstract | Abstract--A synthetic investigation of copper(II) ibuprofenate (lbup) addition compounds with 2,2'-bipyridine (bpy), I ,10-phenanthroline (phen) and 2,9-dimethyl- l ,10-phenanthroline (dmph) has led to the isolation of dinuclear adducts of the forms [Cu(Ibup)i(bpy)b- 4H 20 (1) and [Cu(Ibup)2 (phen)]2 (2) and a mononuclear adduct Cu(lbup)2 (dmph) (3). Spectroscopic data for adducts 1 and 2 are consistent with a dinuclear structure with two CuN 202 + 0 chromophors. Each copper is coordinated with two ibuprofenate bridges, a terminal diimine molecule and a monodentate ibuprofenate group complete five-coordination at each metal atom. Spectroscopic data for adduct 3 are consistent with a mononuclear structure having a very distorted square pyramidal CuN 202 +0 chromophore. The Cuu atom is coordinated to two nitrogen atoms from a chelating dmph ligand, two carboxylic oxygens of a bidentate ibuprofenate ion and an oxygen atom of a monodentate carboxylic group of a second ibuprofenate ion. The reduction of adduct (3) by ascorbic acid produced stable red copper(!) complex of the form [Cu(dmph)i] (Ibup) (4). Spectral data of this adduct indicated that the cation has distorted tetrahedral geometry about the copper atom. The effect of 1 and 2on the rate of hydrolysis of bis(p-nitrophenyl) phosphate (BNPP) have been examined in aqueous methanol solution at 70 C a nd pH7.4. | en_US |
dc.description.sponsorship | Birzeit University | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Pergamon | en_US |
dc.subject | Copper compounds - Therapeutic use | en_US |
dc.subject | Ibuprofen | en_US |
dc.subject | Copper compounds - Synthesis | en_US |
dc.subject | Copper compounds - Spectra | en_US |
dc.subject.lcsh | Copper compounds - Analysis | - |
dc.title | Synthesis and characterization of copper ibuprofenate complexes with 2,2'-bipyridine and 1,10-phenanthrolines and their hydrolytic activities in phosphate diester cleavage | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | Natural Sciences | العلوم الطبيعية | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | other | - |
Appears in Collections: | Fulltext Publications |
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1-s2.0-0277538796002148-main[1].pdf | 641.42 kB | Adobe PDF | View/Open |
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