Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/4040
DC Field | Value | Language |
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dc.contributor.author | Abu Ali, Hijazi | - |
dc.contributor.author | Maloul, Salam | - |
dc.contributor.author | Akkawi, Mutaz | - |
dc.contributor.author | Jaber, Suhair | - |
dc.contributor.author | Abu Ali, Issa | en_US |
dc.date.accessioned | 2017-01-05T11:23:28Z | - |
dc.date.available | 2017-01-05T11:23:28Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/4040 | - |
dc.description.abstract | A nitrogen-based ligand (pyridine-2-yl-undecyl-amine) (1) was synthesized and used for the synthesis of a Zn(II) compound (dichloro-bis(pyridine-2-ylundecyl-amine)zinc(II)) (2). Compound 2 was synthesized and characterized using IR, 1 H NMR, and 13C{1 H} NMR spectroscopy. The crystal structure of 2 was determined using single-crystal X-ray crystallography. The compound was tested for its anti-malarial activity using two methods, a semi-quantitative micro-assay and a previously self-developed quantitative in vitro method. Both methods were used to study the efficiency of 2 to inhibit the formation of the malaria pigment considered an important target of many anti-malarial drugs such as chloroquine and amodaquine. The efficiency of 2 to prevent the formation of β-hematin was 71.4%. The efficiency of amodiaquine as a standard drug was reported at 93.8% | en_US |
dc.language.iso | en | en_US |
dc.subject | Malaria - Treatment | en_US |
dc.subject | Ions in medicine | en_US |
dc.subject | Metals - Therapeutic use | en_US |
dc.title | Dichloro- bis -(pyridine-2-yl-undecylamine) zinc(II), [ZnCl 2 (C 16 N 2 H 26 ) 2 ]. Synthesis, characterization and antimalarial activity | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | none | en_US |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | other | - |
item.grantfulltext | open | - |
Appears in Collections: | Fulltext Publications |
Files in This Item:
File | Description | Size | Format | |
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Dichloro bis pyridine 2 yl undecyl amine zinc II ZnCl2 C16N2H26 2 Synthesis characterization and antimalarial activity (1).pdf | 1.39 MB | Adobe PDF | View/Open |
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