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Title: Dichloro- bis -(pyridine-2-yl-undecylamine) zinc(II), [ZnCl 2 (C 16 N 2 H 26 ) 2 ]. Synthesis, characterization and antimalarial activity
Authors: Abu Ali, Hijazi
Maloul, Salam
Akkawi, Mutaz
Jaber, Suhair
Abu Ali, Issa
Keywords: Malaria - Treatment;Ions in medicine;Metals - Therapeutic use
Issue Date: 2016
Abstract: A nitrogen-based ligand (pyridine-2-yl-undecyl-amine) (1) was synthesized and used for the synthesis of a Zn(II) compound (dichloro-bis(pyridine-2-ylundecyl-amine)zinc(II)) (2). Compound 2 was synthesized and characterized using IR, 1 H NMR, and 13C{1 H} NMR spectroscopy. The crystal structure of 2 was determined using single-crystal X-ray crystallography. The compound was tested for its anti-malarial activity using two methods, a semi-quantitative micro-assay and a previously self-developed quantitative in vitro method. Both methods were used to study the efficiency of 2 to inhibit the formation of the malaria pigment considered an important target of many anti-malarial drugs such as chloroquine and amodaquine. The efficiency of 2 to prevent the formation of β-hematin was 71.4%. The efficiency of amodiaquine as a standard drug was reported at 93.8%
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