Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/3939
DC Field | Value | Language |
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dc.contributor.author | Abdul Ghani, Abdul Salam | |
dc.contributor.author | Abu Hijleh, Abdullatif | |
dc.contributor.author | Qazzaz, Munir | |
dc.contributor.author | Muhaisen, Ashraf | |
dc.contributor.author | Abdul-Ghani, Rula | |
dc.date.accessioned | 2016-12-14T06:48:50Z | |
dc.date.available | 2016-12-14T06:48:50Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/3939 | |
dc.description.abstract | In these experiments we have tested the effect of bis(acetato)tetrakis (imidazole) copper(II) on the release and uptake of 14C-GABA and 3H-glu-tamate from brain slices and brain cortical synaptosomes. Cu(OAc)2(Im)4 in concentrations ranging from 1 to 100 μMhas increased the release of GABA and glutamate from brain slices and synaptosomal preparations in a dose-related manner when the effect on GABA release is two-fold greater than glutamate and 10-fold greater than alanine. Pretreatment with a GABA uptake inhibitor such as 1–2 mMnipecotic acid has no effect on 14C-GABA release, whereas hydroxy aspartate, the glutamate uptake inhibitor, has elevated the stimulated release of glutamate. Copper(II) chloride, the inorganic form of copper, had no significant effect either on GABA release or on glutamate release. The stimulated release of exoge-nous GABA and glutamate was Ca2+ -dependent, because it was inhibited by EGTA, and neuronal, because it was blocked by tetrodotoxin. The recent results can explain the anticonvulsant activity of Cu(OAc)2(Im)4 against strychnine-induced seizures by increasing the net release of GABA from cortical neurons. | |
dc.language.iso | en_US | en_US |
dc.subject | Copper compounds - Physiological effect | en_US |
dc.subject | GABA | en_US |
dc.subject | Glutamic acid - Physiological effect | en_US |
dc.subject | Brain chemistry | en_US |
dc.subject | Synaptosomes | en_US |
dc.subject.lcsh | Anticonvulsants - Mechanism of action | |
dc.title | Stimulated release of exogenous GABA and glutamate from cerebral cortical synaptosomes and brain slices by bis (acetato) tetrakis (imidazole) copper (II) complex | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | Human Biology, Medicine and Health Sciences | الطب والعلوم الطبية | en_US |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | other | - |
item.grantfulltext | open | - |
Appears in Collections: | Fulltext Publications |
Files in This Item:
File | Description | Size | Format | |
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Stimulated Release of Exogenous.pdf | 121.35 kB | Adobe PDF | View/Open |
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