Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/3929
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Abu Hijleh, Abdullatif | - |
dc.contributor.author | Khalaf, Juhienah | - |
dc.date.accessioned | 2016-12-13T12:13:24Z | - |
dc.date.available | 2016-12-13T12:13:24Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/3929 | - |
dc.description.abstract | The synthesis and spectral characterization of binary copper (II) complex of the non-steroidal anti-inflammatory drug naproxen (Nap) with formula [Cu2(Nap)4]n (1) and its ternary complex with 3-pyridylmethanol (3-pym) of formula [Cu(Nap)2(3-pym)2]n (2) were investigated. Complex 1 is polymeric consisting of units of the known paddle-wheel dicopper (II) tetracarboxylates of four naproxenate ions bridging the two copper atoms. The units are axially connected through the neighboring carboxylate oxygen atoms. The X-ray molecular structure measurements of complex 2 showed that it is polymeric consisting of mononuclear units having transe CuN2O2 þO2 chromophores which are bridged by 3-pyridylmethanol ligands through their methanolic oxygen atoms. The measured superoxide dismutase (SOD) mimetic activities of the complexes indicated that complexes 1 and 2 are excellent SOD mimics with an IC50 of 0.30 mM for complex 1 and 0.39 mM for complex 2. The catecholase activities of the complexes toward the aerobic oxidation of 3,5-di-tert-butylcatechol (DTBC) to 3,5-di-tert-butylquinone (DTBQ) showed that both complexes have moderate catalytic oxidase activities. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Copper compounds - Physiological effect | en_US |
dc.subject | Naproxen | en_US |
dc.subject | Superoxide dismutase | en_US |
dc.subject | Anti-inflammatory agents | en_US |
dc.subject.lcsh | Structure-activity relationships (Biochemistry) | - |
dc.subject.lcsh | Naproxen | - |
dc.title | Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase : mimetic activities | en_US |
dc.type | Article | en_US |
newfileds.department | Science | en_US |
newfileds.item-access-type | open_access | en_US |
newfileds.thesis-prog | none | en_US |
newfileds.general-subject | Human Biology, Medicine and Health Sciences | الطب والعلوم الطبية | en_US |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | other | - |
item.grantfulltext | open | - |
Appears in Collections: | Fulltext Publications |
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