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Title: Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase : mimetic activities
Authors: Abu Hijleh, Abdullatif
Khalaf, Juhienah
Keywords: Copper compounds - Physiological effect;Naproxen;Superoxide dismutase;Anti-inflammatory agents
Issue Date: 2010
Abstract: The synthesis and spectral characterization of binary copper (II) complex of the non-steroidal anti-inflammatory drug naproxen (Nap) with formula [Cu2(Nap)4]n (1) and its ternary complex with 3-pyridylmethanol (3-pym) of formula [Cu(Nap)2(3-pym)2]n (2) were investigated. Complex 1 is polymeric consisting of units of the known paddle-wheel dicopper (II) tetracarboxylates of four naproxenate ions bridging the two copper atoms. The units are axially connected through the neighboring carboxylate oxygen atoms. The X-ray molecular structure measurements of complex 2 showed that it is polymeric consisting of mononuclear units having transe CuN2O2 þO2 chromophores which are bridged by 3-pyridylmethanol ligands through their methanolic oxygen atoms. The measured superoxide dismutase (SOD) mimetic activities of the complexes indicated that complexes 1 and 2 are excellent SOD mimics with an IC50 of 0.30 mM for complex 1 and 0.39 mM for complex 2. The catecholase activities of the complexes toward the aerobic oxidation of 3,5-di-tert-butylcatechol (DTBC) to 3,5-di-tert-butylquinone (DTBQ) showed that both complexes have moderate catalytic oxidase activities.
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