ChemInform abstract: studies on the reaction of ferric iron with glutathione and some related thiols. Part III: a study of the iron catalyzed oxidation of glutathione by molecular

Abstract

Complexes formed by mixing iron and reduced glutathione were prepared anaerobically and mixed with oxygen. Rapid kinetic measurements indicated the production of a transient red species, the rate of production of which was oxygen concentration dependent and required one oxygen per two iron atoms. pH studies implicated S anion as a necessary prerequisite. Mijssbauer data indicated that this red complex contained iron(III) whereas the initial complex, prior to oxygenation, contained only iron( A scheme for the iron catalyzed oxidation of glutathione by molecular oxygen is presented.