Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11889/1951
DC Field | Value | Language |
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dc.contributor.author | Hamed, Mazen | - |
dc.contributor.author | Silver, Jack | - |
dc.contributor.author | Wilson, Michael | - |
dc.date.accessioned | 2016-10-08T06:44:51Z | - |
dc.date.available | 2016-10-08T06:44:51Z | - |
dc.date.issued | 1983-12 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11889/1951 | - |
dc.description | Jack,Silver:Brunel University London Michael,Wilson:University of Essex | en_US |
dc.description.abstract | Since the discovery of glutathione (GSH) by Hopkins and the recognition that this thiol could play a role in electron transfer [l-3], there have been many studies of the autocatalytic oxidation of this biologically important compound [l-4] and other related thiols [S-11]. The very low auto-oxidation of cysteine is accelerated by small quantities of iron [5]. And it is interesting to note that iron is always associated with cysteine and glutathione [1, 2, 5, 6, 12, 131 in biological systems. Warburg and Sauma [6] demonstrated that cysteine in aqueous solutions was not oxidized by atmospheric oxygen in the absence of heavy metals and Harrison [2] showed that this was true also for glutathione. The effects of traces of heavy metals like Cu2+ and Fe3+ on the oxidation of cysteine, glutathione, and other thiols have been reported in other studies [ 1,3] . Once the need for the metal catalyst was confirmed [l] , attempts were made to derive a mecha- *Authors to whom correspondence should be addressed. 0020-1693/83/$3.00 nism for this catalytic process [7-l 1, 14, 151. These were based on reduction potentials, reduction capacity and kinetic data | - |
dc.language.iso | en | en_US |
dc.publisher | ResearchGate | en_US |
dc.subject.lcsh | Iron - Chemical reaction | - |
dc.subject.lcsh | Glutathione transferase | - |
dc.title | Studies on the reaction of ferric iron with glutathione and some related thiols. Part III. A study of the iron catalyzed oxidation of glutathione by molecular oxygen | en_US |
dc.type | Article | en_US |
newfileds.department | Department of Chemistry | en_US |
newfileds.item-access-type | open_access | en_US |
item.languageiso639-1 | other | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
Appears in Collections: | Fulltext Publications |
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Studies on the reaction of ferric iron with glutathione and some related thiols. Part III. A study of the iron catalyzed oxidation of glutathione by molecular oxygen.pdf | 731.97 kB | Adobe PDF | View/Open |
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